Mitotic kinases as regulators of cell division and its checkpoints

Nat Rev Mol Cell Biol. 2001 Jan;2(1):21-32. doi: 10.1038/35048096.

Abstract

Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in the choreography of these processes can lead to aneuploidy or genetic instability, fostering cell death or disease. Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission.

Publication types

  • Review

MeSH terms

  • Anaphase / physiology
  • Animals
  • CDC2 Protein Kinase / physiology
  • Cell Division / physiology*
  • Chromosome Aberrations
  • Chromosomes / physiology
  • G2 Phase / physiology
  • Humans
  • Mitosis / physiology*
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Protein Kinases / physiology*
  • S Phase / physiology
  • Signal Transduction
  • Spindle Apparatus / physiology

Substances

  • Protein Kinases
  • CDC2 Protein Kinase