Abstract
The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5%. A 15 min AIDA pre-treatment (10 nmol) selectively counteracted the loss of TH-IR cells caused by MPTP as evaluated 10 days after the insult without changing the total number of non-neuronal cell nuclei. The results suggest that group I mGluR antagonists may have a neuroprotective role against MPTP-induced degeneration of DA neurons and thus probably also against neurodegenerative processes occurring in Parkinson's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
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Animals
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Cell Count
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Cell Size / drug effects
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Coloring Agents
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Dopamine / metabolism*
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Excitatory Amino Acid Antagonists / administration & dosage*
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Immunohistochemistry
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Indans / administration & dosage*
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Injections, Intraventricular
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MPTP Poisoning / pathology
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MPTP Poisoning / prevention & control*
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Male
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Mice
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Mice, Inbred C57BL
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Neurons / drug effects*
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Neurons / pathology
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Neuroprotective Agents / administration & dosage
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Substantia Nigra / drug effects*
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Substantia Nigra / pathology
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Tyrosine 3-Monooxygenase / analysis
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Tyrosine 3-Monooxygenase / biosynthesis
Substances
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1-aminoindan-1,5-dicarboxylic acid
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Coloring Agents
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Excitatory Amino Acid Antagonists
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Indans
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Neuroprotective Agents
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Receptors, Metabotropic Glutamate
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Tyrosine 3-Monooxygenase
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Dopamine