Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity

M X Li; M Jia; H Jiang; V Dunlap; P G Nelson

doi:10.1038/nn0901-871

Opposing actions of protein kinase A and C mediate Hebbian synaptic plasticity

Nat Neurosci. 2001 Sep;4(9):871-2. doi: 10.1038/nn0901-871.

Authors

M X Li¹, M Jia, H Jiang, V Dunlap, P G Nelson

Affiliation

¹ Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Building 49, Room 5A38, National Institutes of Health, Bethesda, Maryland 20892, USA.

PMID: 11528415
DOI: 10.1038/nn0901-871

Abstract

A compartmental nerve-muscle tissue culture system expresses Hebbian activity-dependent synapse modulation. Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that protein kinase A (PKA) is involved in homosynaptic stabilization. Both work through postsynaptic changes in the acetylcholine receptor (AChR) as measured electrophysiologically and by imaging techniques.

MeSH terms

Cyclic AMP-Dependent Protein Kinases / physiology*
Electric Stimulation
Enzyme Activation
Models, Neurological*
Neuronal Plasticity / physiology*
Protein Kinase C / physiology*
Synapses / physiology*
Tetradecanoylphorbol Acetate / pharmacology

Substances

Cyclic AMP-Dependent Protein Kinases
Protein Kinase C
Tetradecanoylphorbol Acetate