Abstract
We investigated the anti-hyperalgesic effect of neutralizing antibodies (AB) to tumor necrosis factor-alpha (TNF) in two murine models of neuropathy, the chronic constrictive sciatic nerve injury (CCI) which has a strong epineurial inflammatory component, and the partial sciatic nerve transection (PST), a 'pure' nerve injury model. In both models a single AB injection intra-operatively as well as on day 4 reduced thermal hyperalgesia significantly, whereas mechanical allodynia was only reduced with intraoperative but not with delayed treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / pharmacology*
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Axons / drug effects
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Axons / immunology
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Axons / pathology
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Behavior, Animal / drug effects*
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Behavior, Animal / physiology
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Disease Models, Animal
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Female
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Hyperalgesia / drug therapy
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Hyperalgesia / metabolism
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Hyperalgesia / physiopathology
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Mice
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Mice, Inbred C57BL
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Mononeuropathies / drug therapy*
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Mononeuropathies / immunology
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Mononeuropathies / pathology
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Nerve Degeneration / drug therapy
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Nerve Degeneration / immunology
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Nerve Degeneration / pathology
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Neuralgia / drug therapy*
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Neuralgia / immunology
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Neuralgia / pathology
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Pain Threshold / drug effects*
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Pain Threshold / physiology
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Sciatic Nerve / drug effects*
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Sciatic Nerve / pathology
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Sciatic Nerve / surgery
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / immunology
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Antibodies
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Tumor Necrosis Factor-alpha