Abstract
During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided strong support for their role as precursor cells in the ventricular zone that generate cortical neurons and glia, in addition to providing migration guidance.
MeSH terms
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Animals
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Astrocytes / chemistry
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Astrocytes / classification*
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Astrocytes / cytology
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Biomarkers / analysis
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Birds / anatomy & histology
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Birds / embryology
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Cell Differentiation
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Cell Lineage
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Central Nervous System / cytology*
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Central Nervous System / embryology
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Cerebral Cortex / cytology
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Cerebral Cortex / embryology
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Chick Embryo
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Genes, Reporter
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Glial Fibrillary Acidic Protein / genetics
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Green Fluorescent Proteins
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Humans
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Luminescent Proteins / analysis
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Mammals / anatomy & histology
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Mammals / embryology
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Mice
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Mice, Transgenic
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Nerve Tissue Proteins / analysis
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Neurons / cytology
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Rats
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Recombinant Fusion Proteins / analysis
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Stem Cells / cytology
Substances
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Biomarkers
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Glial Fibrillary Acidic Protein
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Luminescent Proteins
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Nerve Tissue Proteins
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Recombinant Fusion Proteins
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Green Fluorescent Proteins