Abstract
Understanding the detailed molecular events that support chemical synaptic transmission requires high-resolution methods that provide quantitative information combined with molecular specificity. In recent years, many new technological approaches, including genetically encoded fluorescent indicators, ultra-thin sectioning, and live-cell imaging have been brought to bear on understanding the cell biology and physiology of presynaptic terminals.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Fluorescent Dyes / analysis
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Humans
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Image Processing, Computer-Assisted / methods*
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Neurons / chemistry
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Neurons / physiology
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Presynaptic Terminals / chemistry*
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Presynaptic Terminals / physiology
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Pyridinium Compounds / analysis
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Quaternary Ammonium Compounds / analysis
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Synaptic Transmission / physiology
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Synaptic Vesicles / chemistry
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Synaptic Vesicles / physiology
Substances
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FM1 43
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Fluorescent Dyes
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Pyridinium Compounds
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Quaternary Ammonium Compounds