Glutamate and GABA: a painful combination

A B MacDermott

doi:10.1016/s0896-6273(01)00494-9

Glutamate and GABA: a painful combination

Neuron. 2001 Nov 8;32(3):376-8. doi: 10.1016/s0896-6273(01)00494-9.

Author

A B MacDermott¹

Affiliation

¹ Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

PMID: 11709147
DOI: 10.1016/s0896-6273(01)00494-9

Abstract

Regulation of release of inhibitory neurotransmitter is a key element of plasticity in dorsal horn function. In this issue of Neuron, Kerchner et al. report that neurotransmitter release from inhibitory dorsal horn neurons is affected by activation of presynaptic kainate-type glutamate receptors.

Publication types

Comment

MeSH terms

Animals
Glutamic Acid / biosynthesis
Glutamic Acid / metabolism*
Pain / metabolism*
Posterior Horn Cells / metabolism
Receptors, Kainic Acid / metabolism
gamma-Aminobutyric Acid / biosynthesis
gamma-Aminobutyric Acid / metabolism*

Substances

Receptors, Kainic Acid
Glutamic Acid
gamma-Aminobutyric Acid