Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase

Chembiochem. 2001 Feb 2;2(2):141-3. doi: 10.1002/1439-7633(20010202)2:2<141::AID-CBIC141>3.0.CO;2-P.

Authors

C Arenz¹, M Thutewohl, O Block, H Waldmann, H J Altenbach, A Giannis

Affiliation

¹ Institut für Organische Chemie, Universität Karlsruhe, Richard-Willstätter-Allee 2, 76128 Karlsruhe, Germany.

PMID: 11828438
DOI: 10.1002/1439-7633(20010202)2:2<141::AID-CBIC141>3.0.CO;2-P

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkyl and Aryl Transferases / metabolism
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Brain / enzymology
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
Kinetics
Microsomes / drug effects
Microsomes / enzymology
Polyenes / chemical synthesis
Polyenes / pharmacology*
Polyunsaturated Alkamides
Rats
Signal Transduction
Sphingomyelin Phosphodiesterase / antagonists & inhibitors*
Sphingomyelin Phosphodiesterase / isolation & purification

Substances

Anti-Inflammatory Agents, Non-Steroidal
Enzyme Inhibitors
Polyenes
Polyunsaturated Alkamides
Alkyl and Aryl Transferases
p21(ras) farnesyl-protein transferase
Sphingomyelin Phosphodiesterase
manumycin