Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation

Trends Neurosci. 2002 Mar;25(3):124-6. doi: 10.1016/s0166-2236(00)02094-4.

Abstract

Rhodopsin phosphorylation has provided one of the first examples of the ubiquitous regulatory pattern of specific kinases downregulating the activity of G-protein-coupled receptors. However, only recently have studies in living animals allowed us to consider the role of rhodopsin phosphorylation in a broader spectrum of visual functions, ranging from the ability of rods to generate reproducible electrical responses to their ability to adapt to darkness after substantial light exposures.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrestin / metabolism
  • Cell Membrane / metabolism*
  • Cell Membrane / ultrastructure
  • Dark Adaptation / physiology*
  • Eye Proteins*
  • G-Protein-Coupled Receptor Kinase 1
  • Humans
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Retinal Rod Photoreceptor Cells / metabolism*
  • Retinal Rod Photoreceptor Cells / ultrastructure
  • Rhodopsin / metabolism*
  • Vision, Ocular / physiology*

Substances

  • Arrestin
  • Eye Proteins
  • Rhodopsin
  • Protein Kinases
  • G-Protein-Coupled Receptor Kinase 1
  • GRK1 protein, human