Abstract
Rhodopsin phosphorylation has provided one of the first examples of the ubiquitous regulatory pattern of specific kinases downregulating the activity of G-protein-coupled receptors. However, only recently have studies in living animals allowed us to consider the role of rhodopsin phosphorylation in a broader spectrum of visual functions, ranging from the ability of rods to generate reproducible electrical responses to their ability to adapt to darkness after substantial light exposures.
MeSH terms
-
Animals
-
Arrestin / metabolism
-
Cell Membrane / metabolism*
-
Cell Membrane / ultrastructure
-
Dark Adaptation / physiology*
-
Eye Proteins*
-
G-Protein-Coupled Receptor Kinase 1
-
Humans
-
Phosphorylation
-
Protein Kinases / metabolism*
-
Retinal Rod Photoreceptor Cells / metabolism*
-
Retinal Rod Photoreceptor Cells / ultrastructure
-
Rhodopsin / metabolism*
-
Vision, Ocular / physiology*
Substances
-
Arrestin
-
Eye Proteins
-
Rhodopsin
-
Protein Kinases
-
G-Protein-Coupled Receptor Kinase 1
-
GRK1 protein, human