Abstract
By using a specific antiserum, expression of the 5-HT3 receptor was examined in the petrosal ganglion (PG) of adult male rats. We found that the 5-HT3 receptors are widely distributed in the PG. This finding was confirmed by RT-PCR detection of the 5-HT3 receptor mRNA in the tissue. Unlike the distribution patterns of tyrosine hydroxylase (TH), which occurred in limited regions of PG, the 5-HT3 receptors seemed to distribute throughout the ganglion. As many TH-positive neurons in PG innervate type I cells in the carotid body, the coexistence of 5-HT3 receptor and TH in some neurons suggests that this receptor may play a role in carotid body chemoreception.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cardiovascular Physiological Phenomena
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Carotid Body / physiology*
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Catecholamines / biosynthesis
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Ganglia, Sensory / cytology
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Ganglia, Sensory / metabolism*
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Glossopharyngeal Nerve / cytology
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Glossopharyngeal Nerve / metabolism*
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Immunohistochemistry
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Male
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Neurons, Afferent / cytology
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Neurons, Afferent / metabolism*
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RNA, Messenger / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Serotonin / genetics
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Receptors, Serotonin / metabolism*
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Receptors, Serotonin, 5-HT3
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Reflex / physiology
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Serotonin / metabolism
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Synaptic Transmission / physiology
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Tyrosine 3-Monooxygenase / metabolism*
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Visceral Afferents / cytology
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Visceral Afferents / metabolism*
Substances
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Catecholamines
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RNA, Messenger
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Receptors, Serotonin
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Receptors, Serotonin, 5-HT3
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Serotonin
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Tyrosine 3-Monooxygenase