Abstract
Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Activating Transcription Factor 4
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DNA-Binding Proteins*
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Gene Expression Regulation*
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Macromolecular Substances
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Models, Biological
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Open Reading Frames
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Peptide Initiation Factors / metabolism
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Phosphorylation
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Protein Biosynthesis / physiology*
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Protein Kinases / genetics
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Protein Kinases / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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Saccharomyces cerevisiae Proteins*
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Trans-Activators / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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Fungal Proteins
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Macromolecular Substances
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Peptide Initiation Factors
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RNA, Messenger
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Transcription Factors
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Activating Transcription Factor 4
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Protein Kinases