gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Nat Rev Neurosci. 2002 Apr;3(4):281-90. doi: 10.1038/nrn785.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alzheimer Disease / pathology
  • Alzheimer Disease / physiopathology*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Aspartic Acid Endopeptidases / metabolism
  • Endopeptidases / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Receptors, Notch
  • Trans-Activators / metabolism

Substances

  • Amyloid beta-Peptides
  • Membrane Proteins
  • Receptors, Notch
  • Trans-Activators
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human