Abstract
Similar in vitro experiments were performed on brainstem-spinal cord preparations from mouse and rat neonates to compare the noradrenergic regulations of the respiratory network. In preparations retaining the pons, rhythmic phrenic bursts occurred in rats but not in mice. Transection of the pons, electrolytic lesions and noradrenaline applications showed that the pontine noradrenergic A5 group inhibited the respiratory rhythm generator in both species but the inhibition was especially potent in mice. After pons elimination, noradrenaline applications to the medulla decreased the respiratory frequency in rats but increased it in mice. Noradrenergic agent applications revealed that the frequency changes implicated medullary alpha 1 and alpha 2 noradrenergic receptors in mice and rats, respectively. Thus, interspecies differences seem to exist in the noradrenergic regulations of the rat and mouse medullary respiratory networks.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Adrenergic alpha-Antagonists / pharmacology
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Animals
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Animals, Newborn
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Denervation
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Efferent Pathways / cytology
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Efferent Pathways / drug effects
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Efferent Pathways / metabolism
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Mice
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Neural Inhibition / drug effects
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Neural Inhibition / physiology
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Neurons / cytology
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Neurons / drug effects
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Neurons / metabolism*
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Norepinephrine / metabolism*
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Norepinephrine / pharmacology
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Periodicity*
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Prazosin / pharmacology
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Rats
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Receptors, Adrenergic / drug effects
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Receptors, Adrenergic / metabolism*
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Receptors, Adrenergic, alpha-1 / drug effects
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Receptors, Adrenergic, alpha-1 / metabolism
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Receptors, Adrenergic, alpha-2 / drug effects
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Receptors, Adrenergic, alpha-2 / metabolism
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Respiration / drug effects*
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Respiratory Center / cytology
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Respiratory Center / drug effects
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Respiratory Center / metabolism*
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Rhombencephalon / cytology
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Rhombencephalon / drug effects
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Rhombencephalon / metabolism*
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Spinal Cord / cytology
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Spinal Cord / metabolism
Substances
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Adrenergic alpha-Antagonists
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Receptors, Adrenergic
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Receptors, Adrenergic, alpha-1
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Receptors, Adrenergic, alpha-2
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Norepinephrine
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Prazosin