Abstract
Physical activity, in the form of voluntary wheel running, induces gene expression changes in the brain. Animals that exercise show an increase in brain-derived neurotrophic factor, a molecule that increases neuronal survival, enhances learning, and protects against cognitive decline. Microarray analysis of gene expression provides further support that exercise enhances and supports brain function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Brain / physiology*
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Brain-Derived Neurotrophic Factor / physiology*
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Estrogens / physiology
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Oligonucleotide Array Sequence Analysis
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Physical Conditioning, Animal / physiology*
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Physical Exertion / physiology*
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Synapses / physiology
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Up-Regulation / physiology
Substances
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Brain-Derived Neurotrophic Factor
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Estrogens