Abstract
It has been suggested that Golli proteins, structurally related to myelin basic proteins (MBPs), have a role in autoimmune processes. We studied the expression of these proteins in multiple sclerosis (MS) and determined that the number of Golli-immunoreactive (ir) cells was significantly higher around lesions of chronic MS than in control white matter. Golli proteins were expressed in the adult oligodendrocyte precursor cells (OPCs), activated microglia/macrophages, and some demyelinated axons around MS lesions. Their expression in adult OPCs indicates remyelination attempts, whereas the expression in the subpopulation of microglia/macrophages suggests roles in the immune processes of MS. In addition, Golli proteins may be markers of axonal transection, which is characteristic for MS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Adult
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Aged
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Aged, 80 and over
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Brain / immunology
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Brain / pathology*
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Brain Chemistry*
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Chronic Disease
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Female
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Humans
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Immunohistochemistry
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Macrophages / chemistry
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Macrophages / metabolism
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Macrophages / pathology
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Male
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Microglia / chemistry
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Microglia / metabolism
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Microglia / pathology
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Middle Aged
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Multiple Sclerosis / immunology
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Multiple Sclerosis / metabolism*
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Multiple Sclerosis / pathology
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Myelin Basic Protein
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Nerve Tissue Proteins / analysis*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / immunology
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Oligodendroglia / chemistry
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Oligodendroglia / metabolism
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Oligodendroglia / pathology
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Stem Cells / chemistry
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Stem Cells / metabolism
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Stem Cells / pathology
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Transcription Factors / analysis*
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Transcription Factors / biosynthesis
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Transcription Factors / immunology
Substances
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MBP protein, human
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Myelin Basic Protein
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Nerve Tissue Proteins
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Transcription Factors