Abstract
The gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease 'psoriasis'. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abnormalities, Multiple / metabolism
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Abnormalities, Multiple / pathology
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Differentiation
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Cell Division
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DNA, Complementary
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Epidermis / metabolism
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Epidermis / pathology
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Gene Expression
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Gene Targeting
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Humans
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Keratinocytes / cytology
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Mice
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Mice, Knockout
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Molecular Sequence Data
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology*
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Psoriasis / genetics
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Psoriasis / metabolism*
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Psoriasis / pathology
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Skin Abnormalities / metabolism
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Skin Abnormalities / pathology
Substances
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DNA, Complementary
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LRIG1 protein, human
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Lrig1 protein, mouse
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Membrane Glycoproteins
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Nerve Tissue Proteins
Associated data
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GENBANK/AB050468
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GENBANK/D78572