Abstract
Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up the only precursor population known to migrate away from the surface of the brain. We studied the role of the chemokine stromal-derived factor 1 (SDF-1) in the cerebellar tissue of rats and knockout mice and found (i) that it functions as an attractive guidance cue for neuronal migration and (ii) that its secretion from non-neuronal meningeal tissue is important for controlling the migration of embryonic EGL cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / physiology
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Cell Movement / drug effects
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Cell Movement / physiology
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Cells, Cultured
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Cerebellum / cytology
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Cerebellum / embryology*
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Cerebellum / metabolism*
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Chemokine CXCL12
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Chemokines, CXC / deficiency
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Chemokines, CXC / pharmacology
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Chemokines, CXC / physiology*
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Chemotactic Factors / deficiency
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Chemotactic Factors / pharmacology
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Chemotactic Factors / physiology*
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Coculture Techniques
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Immunohistochemistry
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Kidney / cytology
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Kidney / metabolism
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Meninges / cytology
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Meninges / embryology
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Meninges / metabolism*
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Mice
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Mice, Knockout
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Neurons / cytology
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Neurons / drug effects
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Neurons / metabolism*
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Rats
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Stem Cells / cytology
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Stem Cells / drug effects
Substances
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Chemokine CXCL12
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Chemokines, CXC
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Chemotactic Factors
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Cxcl12 protein, mouse