Cooperation between mglu receptors: a depressing mechanism?

Trends Neurosci. 2002 Aug;25(8):405-11. doi: 10.1016/s0166-2236(02)02228-2.

Abstract

Recent findings from the perirhinal cortex have shed new light on the ways in which metabotropic glutamate receptors could be involved in synaptic plasticity, and in particular in long-term depression (LTD) of synaptic transmission. Importantly, these findings have also led to a greater understanding of mechanisms that could regulate mglu-receptor signalling and the ways in which mglu receptors interact with one another.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Signaling / drug effects
  • Calcium Signaling / physiology
  • Cyclic AMP / metabolism
  • Humans
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Parahippocampal Gyrus / metabolism*
  • Parahippocampal Gyrus / ultrastructure
  • Presynaptic Terminals / drug effects
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / ultrastructure
  • Receptors, Metabotropic Glutamate / drug effects
  • Receptors, Metabotropic Glutamate / metabolism*
  • Receptors, Metabotropic Glutamate / ultrastructure
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synaptic Membranes / drug effects
  • Synaptic Membranes / metabolism*
  • Synaptic Membranes / ultrastructure
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology*

Substances

  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • Cyclic AMP