Abstract
The adult retina is organized into three cellular layers--an outer photoreceptor, a middle interneuron and an inner retinal ganglion cell (RGC) layer. Although the retinal pigment epithelium (RPE) and Müller cells are important in the establishment and maintenance of this organization, the signals involved are unknown. Here we show that Sonic hedgehog signaling from RGCs is required for the normal laminar organization in the vertebrate retina.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Patterning / drug effects
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Body Patterning / genetics*
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Cell Communication / drug effects
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Cell Communication / genetics*
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Cell Differentiation / drug effects
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Cell Differentiation / genetics*
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Cell Division / drug effects
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Cell Division / genetics
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Female
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Gene Expression Regulation, Developmental / drug effects
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Gene Expression Regulation, Developmental / physiology
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Growth Substances / pharmacology
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Hedgehog Proteins
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Male
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Mice
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Mice, Knockout
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Neuroglia / cytology
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Neuroglia / drug effects
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Neuroglia / metabolism
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Phenotype
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Recombinant Fusion Proteins / pharmacology
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Retina / abnormalities*
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Retina / cytology
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Retina / metabolism
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Retinal Ganglion Cells / cytology
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Retinal Ganglion Cells / drug effects
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Retinal Ganglion Cells / metabolism*
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Signal Transduction / drug effects
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Signal Transduction / genetics*
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Stem Cells / cytology
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Stem Cells / metabolism
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Trans-Activators / deficiency*
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Trans-Activators / genetics
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Trans-Activators / pharmacology
Substances
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Growth Substances
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Hedgehog Proteins
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Recombinant Fusion Proteins
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Trans-Activators