Additional signals from VPAC/PAC family receptors

D A McCulloch; C J MacKenzie; M S Johnson; D N Robertson; P J Holland; E Ronaldson; E M Lutz; R Mitchell

doi:10.1042/bst0300441

Additional signals from VPAC/PAC family receptors

Biochem Soc Trans. 2002 Aug;30(4):441-6. doi: 10.1042/bst0300441.

Authors

D A McCulloch¹, C J MacKenzie, M S Johnson, D N Robertson, P J Holland, E Ronaldson, E M Lutz, R Mitchell

Affiliation

¹ MRC Membrane and Adapter Proteins Co-operative Group, Membrane Biology Group, Division of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.

PMID: 12196111
DOI: 10.1042/bst0300441

Abstract

The receptors for the neuropeptides vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide are strong activators of adenylate cyclase, but recent evidence suggests that they can elicit a number of additional intracellular signals. Some of these are likely to be downstream of the conventional adenylate cyclase pathway, but it is now clear that others reflect novel primary coupling events of the receptors.

Publication types

Review

MeSH terms

Animals
Humans
Neuropeptides / physiology
Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, G-Protein-Coupled
Receptors, Gastrointestinal Hormone / physiology
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, Pituitary Hormone / physiology*
Receptors, Vasoactive Intestinal Peptide / physiology*
Second Messenger Systems / physiology
Signal Transduction / physiology*

Substances

ADCYAP1 protein, human
Neuropeptides
Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, G-Protein-Coupled
Receptors, Gastrointestinal Hormone
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
Receptors, Pituitary Hormone
Receptors, Vasoactive Intestinal Peptide
secretin receptor