Abstract
Many cell-surface receptors transmit signals to the nucleus through complex protein cascades. By contrast, the Notch signalling pathway uses a relatively direct mechanism, in which the intracellular domain of the receptor is liberated by intramembrane cleavage and translocates to the nucleus. This critical cleavage is mediated by the gamma-secretase complex, and new findings reveal that this mechanism is used by various receptors, although many questions remain about the biochemical details.
MeSH terms
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Amyloid Precursor Protein Secretases
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Animals
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Aspartic Acid Endopeptidases
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Cell Membrane / enzymology
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Endopeptidases / chemistry
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Endopeptidases / metabolism*
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Humans
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Macromolecular Substances
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Membrane Proteins / metabolism*
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Protein Processing, Post-Translational*
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Protein Transport
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Receptors, Cell Surface / metabolism*
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Receptors, Notch
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Signal Transduction*
Substances
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Macromolecular Substances
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Membrane Proteins
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Receptors, Cell Surface
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Receptors, Notch
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Amyloid Precursor Protein Secretases
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Endopeptidases
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Aspartic Acid Endopeptidases
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BACE1 protein, human