Abstract
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Assay
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Cattle
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Cell Line
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Cerebellum / cytology
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Cerebellum / drug effects
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GPI-Linked Proteins
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Ganglia, Spinal / cytology
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Ganglia, Spinal / drug effects
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Growth Cones / drug effects
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Growth Cones / physiology
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Hippocampus / cytology
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Hippocampus / drug effects
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Humans
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Mice
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Myelin Proteins
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Myelin-Associated Glycoprotein / pharmacology*
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Myelin-Oligodendrocyte Glycoprotein
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Neurites / drug effects*
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Neurites / physiology
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Neurons / cytology
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Neurons / drug effects*
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PC12 Cells
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Rats
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Retinal Ganglion Cells / drug effects
Substances
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GPI-Linked Proteins
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MOG protein, human
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Mog protein, mouse
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Mog protein, rat
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Myelin Proteins
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Myelin-Associated Glycoprotein
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Myelin-Oligodendrocyte Glycoprotein
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OMG protein, human
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Omg protein, mouse
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Omg protein, rat