Abstract
Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.
MeSH terms
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Animals
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Apoptosis
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Apoptosis Inducing Factor
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Cell Death*
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Cell Survival*
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DNA / metabolism*
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Flavoproteins / physiology*
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Free Radical Scavengers / metabolism
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Humans
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Membrane Proteins / physiology*
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Mice
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Models, Biological
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Models, Molecular
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NAD / metabolism
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Oxidation-Reduction*
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Oxidoreductases / physiology
Substances
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AIFM1 protein, human
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Apoptosis Inducing Factor
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Flavoproteins
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Free Radical Scavengers
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Membrane Proteins
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AIFM1 protein, mouse
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NAD
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DNA
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Oxidoreductases