Abstract
The discovery of hair cell regeneration in the inner ear of birds provides new optimism that there may be a treatment for hearing and balance disorders. In this review we describe the process of hair cell regeneration in birds; including restoration of function, recovery of perception and what is currently known about molecular events, such as growth factors and signalling systems. We examine some of the key recent findings in both birds and mammals.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Birds / anatomy & histology
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Birds / growth & development*
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Birds / physiology
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Ear, Inner / growth & development*
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Ear, Inner / injuries*
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Ear, Inner / ultrastructure
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Hair Cells, Auditory / growth & development*
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Hair Cells, Auditory / injuries*
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Hair Cells, Auditory / ultrastructure
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Hearing Loss, Sensorineural / physiopathology
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Hearing Loss, Sensorineural / therapy
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Humans
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Labyrinth Supporting Cells / metabolism
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Labyrinth Supporting Cells / ultrastructure
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Models, Animal
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Nerve Regeneration / physiology*
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Recovery of Function / physiology*
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Signal Transduction / physiology