A diversity of animal models are available for the study of epilepsy and these models have a proven history in advancing our understanding of basic mechanisms underlying epileptogenesis and have been instrumental in the screening of novel antiepileptic drugs. This review addresses the criteria that should be met in a valid animal model and provides an overview of current animal models that are relevant to human conditions. In addition, models not specific for any one human condition but rather exhibiting partial or generalized seizures are discussed. While most human disorders are without any animal model, those models that are clinically relevant have strengths and weaknesses. Finally, although few relevant, well-characterized animal models have been added to the list over recent years, major advancements in molecular genetics are contributing to the discovery of novel pathways involved in epileptogenesis.