Abstract
Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases. Exogenous protein kinase activators increase release probability at several mammalian CNS synapses, but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipid-dependent protein kinase C (PKC) is activated by high-frequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium / metabolism
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Calcium Signaling / drug effects
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Calcium Signaling / physiology
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Electric Stimulation
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Enzyme Inhibitors / pharmacology
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Exocytosis / drug effects
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Exocytosis / physiology
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Glutamic Acid / metabolism
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Hippocampus / drug effects
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Hippocampus / enzymology*
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Organ Culture Techniques
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Presynaptic Terminals / drug effects
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Presynaptic Terminals / enzymology*
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Protein Kinase C / drug effects
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Protein Kinase C / metabolism*
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology
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Rats
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Synaptic Membranes / drug effects
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Synaptic Membranes / metabolism
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology*
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Synaptic Vesicles / drug effects
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Synaptic Vesicles / metabolism
Substances
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Enzyme Inhibitors
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Glutamic Acid
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Protein Kinase C
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Calcium