Abstract
Alpha-synuclein (alphaS) is a protein of unknown function linked to Parkinson's disease. We examined alphaS expression in adrenal medullary chromaffin cells. Immunocytochemistry showed expression of alphaS in the Golgi apparatus and vesicles, consistent with its putative role in vesicular function within synapses, and with O-linked glycosylation of alphaS in autosomal-recessive Parkinson's disease. The chromaffin cell culture system offers advantages in studying the role of alphaS in vesicular trafficking and secretion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenal Medulla / chemistry
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Adrenal Medulla / metabolism*
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Amino Acid Sequence
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Animals
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Cattle
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Chromaffin Cells / chemistry
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Chromaffin Cells / metabolism*
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Female
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Gene Expression Regulation / physiology*
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Golgi Apparatus / chemistry
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Golgi Apparatus / metabolism*
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Molecular Sequence Data
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Rats
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Rats, Sprague-Dawley
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Sequence Homology, Amino Acid
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Synucleins
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alpha-Synuclein
Substances
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Nerve Tissue Proteins
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Snca protein, rat
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Synucleins
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alpha-Synuclein