Abstract
In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Brain Chemistry*
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Chromatography, Thin Layer
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Female
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Frontal Lobe / chemistry
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Gangliosides / analysis*
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Hippocampus / chemistry
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Humans
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Male
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Organ Specificity
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Parietal Lobe / chemistry
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Reference Values
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Substantia Innominata / chemistry
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Telencephalon / chemistry
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Temporal Lobe / chemistry