Abstract
1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain Chemistry / drug effects
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Diazepam / pharmacology*
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Dizocilpine Maleate / antagonists & inhibitors
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Dizocilpine Maleate / pharmacology
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Dopamine / metabolism*
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Homovanillic Acid / metabolism
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Male
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Phencyclidine / antagonists & inhibitors
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Phencyclidine / pharmacology
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Rats
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology*
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Receptors, Phencyclidine
Substances
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Receptors, Neurotransmitter
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Receptors, Phencyclidine
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Dizocilpine Maleate
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Phencyclidine
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Diazepam
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Dopamine
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Homovanillic Acid