Activation of glutamate metabotropic receptors induces long-term potentiation

Z A Bortolotto; G L Collingridge

doi:10.1016/0014-2999(92)90135-q

Activation of glutamate metabotropic receptors induces long-term potentiation

Eur J Pharmacol. 1992 Apr 22;214(2-3):297-8. doi: 10.1016/0014-2999(92)90135-q.

Authors

Z A Bortolotto¹, G L Collingridge

Affiliation

¹ Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, UK.

PMID: 1325361
DOI: 10.1016/0014-2999(92)90135-q

Abstract

The specific glutamate metabotropic receptor agonist 1S,3R-aminocyclopentane dicarboxylate (ACPD), but not its inactive enantiomer 1R,3S-ACPD, induced a slowly developing potentiation of synaptic transmission in rat hippocampal slices. This effect was independent of its ability to potentiate responses mediated by the activation of N-methyl-D-aspartate receptors. Perfusion with 1S,3R-ACPD provides, therefore, a means of chemically inducing a form of long-term potentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cycloleucine / analogs & derivatives
Cycloleucine / pharmacology
Hippocampus / drug effects
Hippocampus / physiology
In Vitro Techniques
Rats
Receptors, Glutamate
Receptors, Neurotransmitter / drug effects
Receptors, Neurotransmitter / physiology*
Synapses / drug effects
Synapses / physiology
Synaptic Transmission / drug effects
Synaptic Transmission / physiology*

Substances

Receptors, Glutamate
Receptors, Neurotransmitter
Cycloleucine
1-amino-1,3-dicarboxycyclopentane