Abstract
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione
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Animals
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Electric Stimulation / methods
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Evoked Potentials / drug effects
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Hippocampus / physiology*
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In Vitro Techniques
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N-Methylaspartate / pharmacology*
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Pyramidal Tracts / physiology*
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Quinoxalines / pharmacology
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Synapses / drug effects
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Synapses / physiology*
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Tetrodotoxin / pharmacology
Substances
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Quinoxalines
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Tetrodotoxin
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N-Methylaspartate
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6-Cyano-7-nitroquinoxaline-2,3-dione