L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

C Thomsen; P Kristensen; E Mulvihill; B Haldeman; P D Suzdak

doi:10.1016/0922-4106(92)90018-q

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

Eur J Pharmacol. 1992 Nov 2;227(3):361-2. doi: 10.1016/0922-4106(92)90018-q.

Authors

C Thomsen¹, P Kristensen, E Mulvihill, B Haldeman, P D Suzdak

Affiliation

¹ Department of Receptor Neurochemistry, CNS Discovery, Novo Nordisk Park, Måløv, Denmark.

PMID: 1361913
DOI: 10.1016/0922-4106(92)90018-q

Abstract

Glutamate and L-AP4 inhibited forskolin-stimulated cyclic AMP (cAMP) production in baby hamster kidney (BHK) cells transfected with the type IV metabotropic receptor (mGluR4). In situ hybridization revealed a high level of mRNA for the mGluR4 in the entorhinal cortex, but not in the dentate gyrus. These data demonstrate that mGluR4 receptors are negatively coupled to the cAMP cascade, and suggest that the mGluR4 receptor may be the previously described presynaptic L-AP4 receptor.

MeSH terms

Adenylyl Cyclases / metabolism*
Aminobutyrates / pharmacology*
Animals
Cells, Cultured
Colforsin / pharmacology
Cricetinae
Cyclic AMP / metabolism
Glutamates / pharmacology
Glutamic Acid
Kidney / cytology
Kidney / metabolism
Receptors, Glutamate / drug effects*

Substances

Aminobutyrates
Glutamates
Receptors, Glutamate
Colforsin
Glutamic Acid
Cyclic AMP
Adenylyl Cyclases
2-amino-4-phosphonobutyric acid