Abstract
Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1) production by astrocytes was enhanced in the injured region. This was associated with increased expression of mRNA for IGF binding protein-3 but not for binding protein-1. In adult rats a single lateral cerebroventricular injection of IGF-1 two hours following a similar injury markedly reduced neuronal loss. It is suggested that endogenous IGF-1 is neurotrophic and that centrally administered IGF-1 may have therapeutic potential for brain injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Astrocytes / physiology*
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Brain / drug effects
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Brain / pathology
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Brain / physiopathology*
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Brain Ischemia / pathology
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Brain Ischemia / physiopathology*
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Brain Ischemia / prevention & control
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Carrier Proteins / genetics
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Cerebral Ventricles / drug effects
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Hypoxia / physiopathology*
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Insulin-Like Growth Factor Binding Proteins
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Insulin-Like Growth Factor I / biosynthesis
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Insulin-Like Growth Factor I / physiology*
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Insulin-Like Growth Factor I / therapeutic use
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Neurons / drug effects
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Neurons / pathology
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Neurons / physiology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Rats
Substances
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Carrier Proteins
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Insulin-Like Growth Factor Binding Proteins
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RNA, Messenger
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Insulin-Like Growth Factor I