Cell death: critical control points

Cell. 2004 Jan 23;116(2):205-19. doi: 10.1016/s0092-8674(04)00046-7.

Abstract

Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Apoptotic Protease-Activating Factor 1
  • Caenorhabditis elegans
  • Calpain / metabolism
  • Cell Death
  • DNA / metabolism
  • Drosophila
  • Endoplasmic Reticulum / metabolism
  • Gene Expression Regulation, Developmental
  • Humans
  • Mitochondria / metabolism
  • Models, Biological
  • Necrosis
  • Proteins / physiology
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Serine Endopeptidases / metabolism
  • Signal Transduction

Substances

  • APAF1 protein, human
  • Apoptotic Protease-Activating Factor 1
  • Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • DNA
  • Serine Endopeptidases
  • Calpain