Vesicle priming and depriming: a SNAP decision

Neuron. 2004 Feb 5;41(3):311-3. doi: 10.1016/s0896-6273(04)00039-x.

Abstract

Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cells, Cultured
  • Cyclic AMP-Dependent Protein Kinases / metabolism
  • Exocytosis*
  • Humans
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Nerve Tissue Proteins / metabolism*
  • Neurons / metabolism
  • Phosphorylation
  • Synaptic Transmission
  • Synaptic Vesicles / metabolism*
  • Synaptosomal-Associated Protein 25

Substances

  • Membrane Proteins
  • Nerve Tissue Proteins
  • SNAP25 protein, human
  • Synaptosomal-Associated Protein 25
  • Cyclic AMP-Dependent Protein Kinases