Abstract
Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and posttranslational modifications of SNAP-25 may therefore affect synaptic strength.
MeSH terms
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Animals
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Cells, Cultured
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Cyclic AMP-Dependent Protein Kinases / metabolism
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Exocytosis*
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Humans
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Membrane Proteins / metabolism*
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Models, Biological
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Nerve Tissue Proteins / metabolism*
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Neurons / metabolism
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Phosphorylation
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Synaptic Transmission
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Synaptic Vesicles / metabolism*
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Synaptosomal-Associated Protein 25
Substances
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Membrane Proteins
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Nerve Tissue Proteins
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SNAP25 protein, human
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Synaptosomal-Associated Protein 25
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Cyclic AMP-Dependent Protein Kinases