Abstract
The developmental processes of maturation in the CNS are the result of specific events including mitogenesis, differentiation, and cell death which occur in a precise spatial and temporal manner. It has been reported that many transcription factors, including forkhead transcription factors, play a key role in these processes. First, we examined the expression pattern of the forkhead transcription factor Foxp1 in the adult CNS. Foxp1 was highly expressed in the striatum and moderately in the cerebral cortex, CA1/2 subfields of the hippocampus, and several thalamic nuclei. In situ hybridization combined with immunohistochemistry in the striatum of adult mice revealed that Foxp1 mRNA was detected in a subset of projection neurons, not in interneurons. In addition, the expression of Foxp1 mRNA was observed in the developing basal ganglia with the exception of the globus pallidus. Thus, Foxp1 mRNA was expressed in a subset of striatal projection neurons, probably the matrix neurons. The expression pattern of Foxp1 mRNA suggests that Foxp1 may play a role in the development and formation of a circuit in the basal ganglia, which is involving the matrix neurons.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Blotting, Northern / methods
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Brain / anatomy & histology
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Brain / metabolism
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Cell Count
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Choline O-Acetyltransferase / metabolism
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Corpus Striatum / cytology*
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Corpus Striatum / physiology
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Dopamine and cAMP-Regulated Phosphoprotein 32
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Embryo, Mammalian
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Forkhead Transcription Factors
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Gene Expression
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Gene Expression Regulation, Developmental
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Immunohistochemistry / methods
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In Situ Hybridization / methods
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Mice
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Mice, Inbred C57BL
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / metabolism
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Nerve Tissue Proteins*
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Neural Pathways / metabolism*
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Neurons / metabolism*
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Neuropeptide Y / metabolism
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Parvalbumins / metabolism
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Phosphoproteins / genetics
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Phosphoproteins / metabolism
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RNA, Messenger / metabolism
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Receptors, AMPA / genetics
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Receptors, AMPA / metabolism
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Repressor Proteins / genetics
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Repressor Proteins / metabolism*
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gamma-Aminobutyric Acid / metabolism
Substances
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Dopamine and cAMP-Regulated Phosphoprotein 32
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Forkhead Transcription Factors
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Foxp1 protein, mouse
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Microtubule-Associated Proteins
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Nerve Tissue Proteins
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Neuropeptide Y
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Parvalbumins
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Phosphoproteins
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RNA, Messenger
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Receptors, AMPA
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Repressor Proteins
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gamma-Aminobutyric Acid
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Choline O-Acetyltransferase
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glutamate receptor ionotropic, AMPA 2