Abstract
Radial glial cells function during CNS development as neural progenitors, although their precise contribution to neurogenesis remains controversial. Recent work has argued that regional differences may exist regarding the neurogenic potential of radial glia. Here, we show that the vast majority of neurons in all brain regions derive from radial glia. Cre/loxP fate mapping and clonal analysis demonstrate that radial glia throughout the CNS serve as neuronal progenitors and that radial glia within different regions of the CNS pass through their neurogenic stage of development at distinct time points. Thus, radial glial populations within different CNS regions are not heterogeneous with regard to their potential to generate neurons versus glia.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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5' Flanking Region / genetics
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Animals
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Biomarkers
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Body Patterning / genetics
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Cell Differentiation / genetics*
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Cell Lineage / genetics
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Cell Movement / genetics
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Central Nervous System / cytology
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Central Nervous System / embryology*
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Central Nervous System / metabolism
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Clone Cells / cytology
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Clone Cells / metabolism
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Fatty Acid-Binding Protein 7
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Fatty Acid-Binding Proteins
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Fetus
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Gene Expression Regulation, Developmental / genetics
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Mice
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Mice, Transgenic
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Neuroglia / cytology
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Neuroglia / metabolism*
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Neurons / cytology
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Neurons / metabolism*
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Recombination, Genetic / genetics
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Stem Cells / cytology
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Stem Cells / metabolism*
Substances
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Biomarkers
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Carrier Proteins
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Fabp7 protein, mouse
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Fatty Acid-Binding Protein 7
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Fatty Acid-Binding Proteins
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Nerve Tissue Proteins