Danger, death and DNA vaccines

Elke S Bergmann-Leitner; Wolfgang W Leitner

doi:10.1016/j.micinf.2003.11.015

Danger, death and DNA vaccines

Microbes Infect. 2004 Mar;6(3):319-27. doi: 10.1016/j.micinf.2003.11.015.

Authors

Elke S Bergmann-Leitner¹, Wolfgang W Leitner

Affiliation

¹ Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. Elke.Bergmann-Leitner@na.amedd.army.mil

PMID: 15065568
DOI: 10.1016/j.micinf.2003.11.015

Abstract

DNA vaccines, although successful in many animal models of various diseases, remain insufficiently immunogenic in humans. Among the countless approaches to improve them is the stimulation of the innate immune system by promoting the apoptotic death of the transfected host cells, which is the focus of this review.

Publication types

Review

MeSH terms

Adjuvants, Immunologic / administration & dosage
Animals
Antigen-Presenting Cells / immunology
Apoptosis*
Humans
Immunity, Innate*
Lymphocyte Activation / immunology
Plasmids
Vaccines, DNA / immunology*

Substances

Adjuvants, Immunologic
Vaccines, DNA