Abstract
The protein p42IP4 (centaurin-alpha1) is a brain-specific InsP4/PtdIns3 (PIP)-binding protein, whish is localized in neurons of the human brain. In Alzheimer's disease (AD) the intraneuronal expression of the protein was shown to be elevated. In addition, p42IP4 immunostaining decorated neuritic plaques. Attempting to explain the putative role of the protein in AD, we have concentrated on its well-known interactions with casein kinase I, which is known to be prominently involved in AD pathophysiology. Meanwhile, specific interaction of p42IP4 with nucleolin, another player in AD pathology, has been revealed. Based on these data, we propose alternative concepts of how p42IP4 might act in AD pathomechanisms.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Animals
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Brain / metabolism*
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Brain / pathology
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Carrier Proteins / biosynthesis*
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Carrier Proteins / genetics
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Gene Expression Regulation / physiology
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Humans
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Nucleolin
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Phosphoproteins / metabolism*
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RNA-Binding Proteins / metabolism*
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Receptors, Cytoplasmic and Nuclear / biosynthesis*
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Receptors, Cytoplasmic and Nuclear / genetics
Substances
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ADAP1 protein, human
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Nerve Tissue Proteins
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Phosphoproteins
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RNA-Binding Proteins
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Receptors, Cytoplasmic and Nuclear
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inositol-1,3,4,5-tetrakisphosphate receptor