p75NTR is positively promiscuous: novel partners and new insights

Neuron. 2004 May 27;42(4):529-33. doi: 10.1016/j.neuron.2004.04.001.

Abstract

Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Cell Death / physiology
  • Cell Survival / physiology
  • Humans
  • Ligands
  • Membrane Glycoproteins / metabolism
  • Myelin Proteins / metabolism
  • Nerve Growth Factors / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Nervous System / growth & development
  • Nervous System / metabolism*
  • Nogo Proteins
  • Protein Binding / physiology
  • Receptor, Nerve Growth Factor
  • Receptors, Nerve Growth Factor / metabolism*

Substances

  • Adaptor Proteins, Vesicular Transport
  • Ligands
  • Membrane Glycoproteins
  • Myelin Proteins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Receptor, Nerve Growth Factor
  • Receptors, Nerve Growth Factor
  • sortilin