Abstract
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal
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Carrier Proteins / genetics*
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Chromosome Mapping
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Cloning, Molecular / methods
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Embryo, Mammalian
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Ethanol
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Gene Expression
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Genetic Predisposition to Disease*
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Genotype
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Membrane Proteins
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Mice
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Mice, Congenic
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Mice, Inbred C57BL
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Molecular Sequence Data
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Quantitative Trait Loci / genetics*
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Seizures / etiology
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Seizures / genetics*
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Substance Withdrawal Syndrome / complications
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Substance Withdrawal Syndrome / genetics*
Substances
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Carrier Proteins
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Membrane Proteins
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Mpdz protein, mouse
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Ethanol
Associated data
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GENBANK/CK085026
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GENBANK/CK085027
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GENBANK/CK085028
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GENBANK/CK085029
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GENBANK/CK085030
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GENBANK/CK085031