Mpdz is a quantitative trait gene for drug withdrawal seizures

Nat Neurosci. 2004 Jul;7(7):699-700. doi: 10.1038/nn1271. Epub 2004 Jun 20.

Abstract

Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal
  • Carrier Proteins / genetics*
  • Chromosome Mapping
  • Cloning, Molecular / methods
  • Embryo, Mammalian
  • Ethanol
  • Gene Expression
  • Genetic Predisposition to Disease*
  • Genotype
  • Membrane Proteins
  • Mice
  • Mice, Congenic
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Quantitative Trait Loci / genetics*
  • Seizures / etiology
  • Seizures / genetics*
  • Substance Withdrawal Syndrome / complications
  • Substance Withdrawal Syndrome / genetics*

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Mpdz protein, mouse
  • Ethanol

Associated data

  • GENBANK/CK085026
  • GENBANK/CK085027
  • GENBANK/CK085028
  • GENBANK/CK085029
  • GENBANK/CK085030
  • GENBANK/CK085031