Turning on the machine: genetic control of axon regeneration by c-Jun

Feng-Quan Zhou; Mark A Walzer; William D Snider

doi:10.1016/j.neuron.2004.06.020

Turning on the machine: genetic control of axon regeneration by c-Jun

Neuron. 2004 Jul 8;43(1):1-2. doi: 10.1016/j.neuron.2004.06.020.

Authors

Feng-Quan Zhou¹, Mark A Walzer, William D Snider

Affiliation

¹ Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

PMID: 15233911
DOI: 10.1016/j.neuron.2004.06.020

Abstract

Upregulation of the transcription factor c-Jun has been correlated with axon regeneration after injury in multiple types of neurons. In this issue of Neuron, Raivich et al. use a nervous system-specific mutant to provide genetic evidence that c-Jun is necessary for efficient axon regeneration.

Publication types

Comment
Review

MeSH terms

Animals
Axons / physiology*
Facial Nerve Injuries / genetics
Facial Nerve Injuries / metabolism
Gene Expression Regulation, Developmental / genetics
Mice
Mice, Knockout / genetics
Mice, Knockout / growth & development
Mice, Knockout / metabolism
Nerve Regeneration / genetics*
Nervous System / cytology
Nervous System / growth & development*
Nervous System / metabolism
Neuronal Plasticity / genetics*
Proto-Oncogene Proteins c-jun / genetics*
Transcriptional Activation / genetics

Substances

Proto-Oncogene Proteins c-jun