Epothilone D (Kosan/Roche)

Curr Opin Investig Drugs. 2004 Jun;5(6):657-67.

Abstract

Kosan and Roche are developing the microtubule inhibitor epothilone D (KOS-862 and NSC-703147), an analog of epothilone B for the potential treatment of cancer. Phase II trials in colorectal, metastatic breast and non-small-cell lung cancers were initiated in December 2003.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Clinical Trials, Phase III as Topic
  • Drug Evaluation, Preclinical
  • Drugs, Investigational / adverse effects
  • Drugs, Investigational / chemistry
  • Drugs, Investigational / pharmacology
  • Drugs, Investigational / therapeutic use*
  • Epothilones / adverse effects
  • Epothilones / chemistry
  • Epothilones / pharmacology
  • Epothilones / therapeutic use*
  • Humans

Substances

  • Antineoplastic Agents
  • Drugs, Investigational
  • Epothilones
  • desoxyepothilone B