Abstract
Intracellular transport by microtubule-dependent motors is crucial for neuronal survival and function. Recent advances reveal novel strategies for the regulation of transport and the attachment of motors to cargoes. Current findings also illustrate the importance of directed transport in neuronal biology, including microtubule-motor-dependent transduction of neurotrophic signals and axonal damage signal complexes. Furthermore, recent data implicating the dysfunction of microtubule-dependent transport in the cause and development of several neurodegenerative diseases provides evidence for the vital role of transport in neuronal and organismal function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Axonal Transport
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Biological Transport
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Dynactin Complex
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Humans
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Huntingtin Protein
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Kinesins / metabolism
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Microtubule-Associated Proteins / metabolism
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Microtubules / metabolism*
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Models, Biological
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Motor Neurons / physiology*
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Nerve Tissue Proteins / metabolism
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology
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Nuclear Proteins / metabolism
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Protein Sorting Signals
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Second Messenger Systems
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Signal Transduction
Substances
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Dynactin Complex
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HTT protein, human
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Huntingtin Protein
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KIF1A protein, human
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Microtubule-Associated Proteins
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Nerve Tissue Proteins
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Nuclear Proteins
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Protein Sorting Signals
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Kinesins