Abstract
Recent years have seen an explosion in the rate of discovery of genetic defects linked to Parkinson's disease. These breakthroughs have not provided a direct explanation for the disease process. Nevertheless, they have helped transform Parkinson's disease research by providing tangible clues to the neurobiology of the disorder.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Dopamine / metabolism
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Genetic Predisposition to Disease*
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Humans
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Intracellular Signaling Peptides and Proteins
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Leukocyte Common Antigens / genetics
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Leukocyte Common Antigens / metabolism
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Models, Neurological
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Mutation / genetics
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Nerve Degeneration / genetics
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Nerve Degeneration / pathology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism
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Parkinson Disease / genetics*
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Parkinson Disease / pathology
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Protein Deglycase DJ-1
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Synucleins
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Ubiquitin-Protein Ligases / genetics*
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Ubiquitin-Protein Ligases / metabolism
Substances
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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Oncogene Proteins
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Synucleins
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Ubiquitin-Protein Ligases
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parkin protein
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PARK7 protein, human
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Protein Deglycase DJ-1
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Leukocyte Common Antigens
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Dopamine