Abstract
Ca(2+) influx via reversed K(+)-dependent (NCKX) and/or K(+)-independent (NCX) plasmalemmal Na(+)/Ca(2+) exchangers may play a role in neuronal death following global brain ischemia to which CA1 neurons are particularly vulnerable. Therefore, this work tested whether the rates of Ca(2+) influx via reversed NCKX or NCX in cultured rat CA1 neurons differ from those in forebrain neurons (FNs) or cerebellar granule cells (CGCs). The NCKX-mediated Ca(2+) influx was several times more rapid in CA1 neurons than in FNs or CGCs and was not affected by Na(+)/Ca(2+) exchange inhibitors, KB-R7943 or bepridil. NCKX reversal inhibitors are not yet available. Their development would greatly facilitate further testing the role of NCKX in ischemic death of CA1 neurons.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium / metabolism*
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Cells, Cultured
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Cesium / pharmacology
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Embryo, Mammalian
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Excitatory Amino Acid Antagonists / pharmacology
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Female
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Gluconates / pharmacology
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Gramicidin / pharmacology
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Hippocampus / cytology*
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Ion Transport / drug effects
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Lithium / pharmacology
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Male
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Meglumine / analogs & derivatives*
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Meglumine / pharmacology
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Neurons / drug effects
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Neurons / metabolism*
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Potassium / metabolism*
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Pregnancy
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Quinoxalines / pharmacology
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Rats
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Sodium / metabolism*
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Sodium-Calcium Exchanger / agonists
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Sodium-Calcium Exchanger / antagonists & inhibitors
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Sodium-Calcium Exchanger / drug effects
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Sodium-Calcium Exchanger / metabolism*
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Thiourea / analogs & derivatives*
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Thiourea / pharmacology
Substances
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2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
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Excitatory Amino Acid Antagonists
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Gluconates
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Quinoxalines
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Sodium-Calcium Exchanger
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N-methylglucamine gluconate
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2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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Gramicidin
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Cesium
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Meglumine
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Lithium
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Sodium
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Thiourea
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Potassium
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Calcium