NF-kappaB signaling: flipping the switch with polyubiquitin chains

Tommer Ravid; Mark Hochstrasser

doi:10.1016/j.cub.2004.09.074

NF-kappaB signaling: flipping the switch with polyubiquitin chains

Curr Biol. 2004 Oct 26;14(20):R898-900. doi: 10.1016/j.cub.2004.09.074.

Authors

Tommer Ravid¹, Mark Hochstrasser

Affiliation

¹ Yale University, Department of Molecular Biophysics & Biochemistry, 266 Whitney Avenue, P.O. Box 208114 New Haven, Connecticut 06520-8114, USA.

PMID: 15498483
DOI: 10.1016/j.cub.2004.09.074

Abstract

Protein modification by ubiquitin has emerged as an important cellular regulatory mechanism. Recent studies illustrate the surprising ways in which polyubiquitin chains are manipulated in the regulation of NF-kappaB signaling.

Publication types

Review

MeSH terms

Gene Expression Regulation*
Models, Biological*
NF-kappa B / metabolism*
NF-kappa B / physiology
Phosphorylation
Polyubiquitin / metabolism*
Protein Processing, Post-Translational / physiology*
Proteins / metabolism
Signal Transduction / physiology*
Tumor Necrosis Factor-alpha / metabolism

Substances

NF-kappa B
Proteins
Tumor Necrosis Factor-alpha
Polyubiquitin