Divide et Impera--the midbrain-hindbrain boundary and its organizer

Florian Raible; Michael Brand

doi:10.1016/j.tins.2004.10.003

Divide et Impera--the midbrain-hindbrain boundary and its organizer

Trends Neurosci. 2004 Dec;27(12):727-34. doi: 10.1016/j.tins.2004.10.003.

Authors

Florian Raible¹, Michael Brand

Affiliation

¹ Max-Planck Institute of Molecular Cell Biology and Genetics, and Department of Genetics, University of Technology, Dresden, Pfotenhauerstrasse 108, D-01309 Dresden, Germany. .

PMID: 15541513
DOI: 10.1016/j.tins.2004.10.003

Abstract

The midbrain-hindbrain organizer (MHO) is a signalling centre that orchestrates development of the mesencephalic and anterior metencephalic primordia. In recent years, details have been revealed about the molecular nature of these signals, their transmission and reception, and the regulatory processes associated with MHO function. This article reviews recent progress in understanding the genetic and molecular components of the MHO, and how they synergize to control brain development.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biological Evolution
Gene Expression Regulation, Developmental
Growth Substances / metabolism
Mesencephalon* / anatomy & histology
Mesencephalon* / embryology
Mesencephalon* / physiology
Morphogenesis
Neurons / physiology
Organizers, Embryonic*
Rhombencephalon* / anatomy & histology
Rhombencephalon* / embryology
Rhombencephalon* / physiology
Signal Transduction / physiology

Substances

Growth Substances