Abstract
Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.
Publication types
-
Comparative Study
-
Evaluation Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Brain Neoplasms / blood supply*
-
Brain Neoplasms / pathology*
-
Cell Line, Tumor
-
Contrast Media / administration & dosage
-
Corpus Striatum / blood supply
-
Corpus Striatum / pathology
-
Dextrans
-
Dose-Response Relationship, Drug
-
Ferrosoferric Oxide
-
Glioma / blood supply
-
Glioma / pathology
-
Image Enhancement / methods
-
Iron / administration & dosage*
-
Magnetic Resonance Imaging / methods*
-
Magnetite Nanoparticles
-
Male
-
Microcirculation / pathology*
-
Neovascularization, Pathologic / pathology*
-
Oxides / administration & dosage*
-
Rats
-
Rats, Wistar
-
Reproducibility of Results
-
Sensitivity and Specificity
Substances
-
Contrast Media
-
Dextrans
-
Magnetite Nanoparticles
-
Oxides
-
ferumoxtran-10
-
Iron
-
Ferrosoferric Oxide