Abstract
While oligodendrocyte precursors have previously been localized to the ventral midline, two papers in this issue of Neuron (Cai et al. and Vallstedt et al.) provide compelling evidence for a second dorsal origin of oligodendrocyte precursors in the spinal cord and hindbrain. These cells share expression of the PDGFalpha receptor and Olig2 with their ventral counterparts but differ in the requirement for Nkx6 and hedgehog signaling.
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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Cell Differentiation / physiology*
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Central Nervous System / cytology
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Central Nervous System / embryology*
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Hedgehog Proteins
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Homeodomain Proteins / metabolism
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Humans
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Nerve Tissue Proteins / metabolism
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Oligodendrocyte Transcription Factor 2
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Oligodendroglia / cytology
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Oligodendroglia / physiology*
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Receptor, Platelet-Derived Growth Factor alpha / metabolism
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Stem Cells / cytology
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Stem Cells / physiology*
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Trans-Activators / metabolism
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Hedgehog Proteins
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Homeodomain Proteins
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Nerve Tissue Proteins
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Nkx6-1 protein, mouse
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OLIG2 protein, human
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Olig2 protein, mouse
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Oligodendrocyte Transcription Factor 2
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Trans-Activators
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Receptor, Platelet-Derived Growth Factor alpha